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Simulator005
"WorldRatchet"
S005 simulates
Muller's ratchet in a single asexual population to determine
rates of genomic decay for many different parameter combinations
of mutation rate, selection coefficient and population size.
The constant onslaught of slightly deleterious mutations
may be a significant cause of exinction of species on the
long term. This simulator helps to uncover the true extent
of the problem in asexual genomes. The results have implications
for all non-recombining genomes such as mitochondrial DNA
in humans or other organisms. They further help estimate the
importance of horizontal gene-transfer in bacteria and deepen
our understanding of the importance of sex (= regular recombination
of genetic material) for long term survival of organisms.
Thus, in a broader sense, the results computed by this simulator
help understand more about the origins and evolution of life
on our wonderful planet earth.
We would like
to invite you to be part of one of the most fascinating adventures
on this planet: the quest for origins. Just download
the simulator and feed in some run-files
to keep your computer busy while you relax. We hope you enjoy
the evolutionary research you are doing and wish you a pleasant
computing experience.
As this simulator currently has no networking capabilities,
it depends on your manual supply of input run-files (=run.txt)
and your submission of output (= S005_RESULTS.txt, formerly
results.S005.txt) via email. You find all details in the files
generated by the simulator in the folder, where you had put
it in.
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